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In the early 1960s one of the projects in the searle research laboratories was to find an inhibitor of the gastrointestinal secretory hormone gastrin as. For example, a 12 ounce diet soft drink might contain about 125 mg (0.125 gram) of aspartame, which would have less than 1. Aspartame is a caloric substance because it is a dipeptide that is completely digested after consumption. This artificial sweetener has been around since the late 1800s (making it the oldest artificial sweetener) and is 200 to 700 times sweeter than sugar. This book summarizes the research that resulted in aspartame�s approval as a food additive as well as related topics regarding its function as a potential sweetening agent. Aspartame has been approved for food, beverage, pharmaceutical, and tabletop sweetener use in more than 100 countries.
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